张艳，教授，博导，威尼斯wnsr888副经理。1997年于吉林大学获学士学位，2002年于南京大学获博士学位，2002-2004年在香港科技大学化学系做博士后，2004-2006年在斯坦福大学医学院做博士后。2006年9月加入南京大学任威尼斯wnsr888(亚洲)集团有限公司教授，2016年起任威尼斯wnsr888(亚洲)集团有限公司副经理。入选南京大学首批登峰B人才支持计划，获首批江苏省杰出青年基金，入选中组部第二批青年拔尖人才支持计划。主要研究领域为光化员工物学，以通讯作者在J. Am. Chem. Soc.、Angew. Chem. Int. Ed.等期刊发表SCI论文多篇。任江苏省化学化工学会理事会化员工物学专业委员会主任委员、中国感光学会光化学及光生物专业委员会副主任、中国化学会青委会委员等。目前主持国家自然科学基金重点项目、面上项目等。

从反应瓶中的光反应到活细胞上的光反应

主要研究方向为光化员工物学，包括光驱动生物正交反应的开发及化员工物学应用。

针对解析生命体系内复杂、动态分子事件对于时空分辨型分子探针的急迫需求，借助光诱导实现对复杂生物环境中生物正交官能团间反应的精准控制，为光诱导成键反应这一传统的有机化学反应找到在构建时空分辨的分子探针这一化员工物学新应用，促进光化学与生命科学研究的交叉和融合。

1.Xi, Z.; Kong, H.; Chen, Y.; Deng, J.; Xu,W.; Liang,Y.; Zhang, Y. Metal- and Strain-Free Bioorthogonal Cycloaddition of o-Diones with Furan-2(3H)-one as Anionic Cycloaddend, Angew. Chem. Int. Ed. 2022, e202200239

2.Wang,Y.; Bai, H.; Miao, Y.; Weng, J.; Huang, Z.; Fu, J.; Zhang, Y.;Lin, J.; Ye, D. Tailoring a Near-Infrared Macrocyclization Scaffold Allows the Control of In Situ Self-Assembly for Photoacoustic/ PET Bimodal Imaging, Angew. Chem. Int. Ed. 2022, e202200369.

3.Wang, X.; Xiao X.; Feng, Y.; Li, J.; Zhang, Y.A photoresponsive antibody-siRNA conjugate for activatable immunogene therapy of cancer, Chem. Sci. 2022, 11, 3390-3396.

4.Chen, L.; Li, G.; Wang, X.; Li, J.;Zhang, Y. Spherical Nucleic Acids for Near-Infrared Light-Responsive Self-Delivery of Small-Interfering RNA and Antisense Oligonucleotide, ACS Nano, 2021, 15, 11929-11939.

5.Wang, Y.; Weng, J.; Lin, J.; Ye, D.; Zhang, Y. NIR Scaffold Bearing Three Handles for Biocompatible Sequential Click Installation of Multiple Functional Arms, J. Am. Chem. Soc. 2020, 142, 2787-2794.

6.Li, J.; Kong, H. Zhu, C.; Zhang, Y. Photo-controllable bioorthogonal chemistry for spatiotemporal control of bio-targets in living systems, Chem. Sci. 2020, 11, 3390-3396.

7.Chen, L.; Sun, Y.;Li, J.;Zhang, Y. Photoactivatable microRNA probe for identification of microRNA targets and light-controlled suppression of microRNA target expression, Chem. Commun., 2020, 56, 627- 630.

8.Wang, Y.; Hu, X.; Weng, J.; Li, J.; Fan, Q.; Zhang, Y.; Ye, D.  A Photoacoustic Probe for the Imaging of Tumor Apoptosis by Caspase-Mediated Macrocyclization and Self-Assembly. Angew. Chem. Int. Ed. 2019, 58, 4886-4890.

9.Wang, X.;Xiao, X.;Zhang, B.;Li, J.; Zhang, Y.A self-assembled peptide nucleic acid-microRNA nanocomplex for dual-modulation of cancer-related microRNAs.Chem. Commun. 2019, 55, 2106-2109.

10.Li, J.; Kong, H.; Huang, L.; Cheng, B.; Qin, K.; Zheng M.; Yan, Z.; Zhang, Y. Visible Light-Initiated Bioorthogonal Photoclick Cycloaddition. J. Am. Chem. Soc. 2018, 140, 14542-14546.

11.Xiao, X.; Wang, X.; Wang, Y.; Yu, T.; Huang, L.; Chen, L.; Li, J.; Zhang, C.; Zhang, Y. Multi-functional Peptide-MicroRNA Nanocomplex for Targeted MicroRNA Delivery and Function Imaging. Chem. Eur. J. 2018, 24, 2277-2285.

12.Xiao, X.; Wang, X.; Gao, H.; Chen, X.;  Li, J.; Zhang, Y. Cell-Selective Delivery of MicroRNA with a MicroRNA-Peptide Conjugate Nanocomplex.Chem. Asian J. 2018, 13, 3845-3849.

13.Zhou, Z.; Xie, X.; Yi, Q.; Yin, W.; Kadi, A. A.; Li, J.; Zhang, Y. Enzyme-instructed self-assembly with photo-responses for the photo-regulation of cancer cells. Org. Biomol. Chem. 2017, 15, 6892-6895.

14.Huang, L.; Chen, Y.; Chen, L.; Xiao, X.; Wang, X.; Li, J.; Zhang, Y. Photo-clickable microRNA for in situ fluorescence labeling and imaging of microRNA in living cells. Chem. Commun. 2017, 53, 6452-6455.

15.Zhou, Z.; Yi, Q.; Xia, T.; Yin, W.; Kadi, A. A.; Li, J.; Zhang, Y. A photo-degradable supramolecular hydrogel for selective delivery of microRNA into 3D-cultured cells. Org. Biomol. Chem. 2017, 15, 2191-2198.

16.Li, J.; Huang, L.; Xiao, X.; Chen, Y.; Wang, X.; Zhou, Z.; Zhang, C.; Zhang, Y. Photoclickable MicroRNA for the Intracellular Target Identification of MicroRNAs. J. Am. Chem. Soc. 2016, 138, 15943-15949.

17.Wang, Y.; Li, J.; Feng, L.; Yu, J.; Zhang, Y.; Ye, D.; Chen, H. Y. Lysosome-Targeting Fluorogenic Probe for Cathepsin B Imaging in Living Cells. Anal. Chem. 2016, 88, 12403-12410.

18.Zheng, M.; Wang, Y.; Shi, H.; Hu, Y.; Feng, L.; Luo, Z.; Zhou, M.; He, J.; Zhou, Z.; Zhang, Y.; Ye, D. Redox-Mediated Disassembly to Build Activatable Trimodal Probe for Molecular Imaging of Biothiols. ACS Nano, 2016, 10, 10075-10085.

19.Xiao, X.; Hu, J.; Wang, X.; Huang, L.; Chen, Y.; Wang, W.; Li, J.; Zhang, Y. A dual-functional supramolecular hydrogel based on a spiropyran-galactose conjugate for target-mediated and light-controlled delivery of microRNA into cells. Chem. Commun. 2016, 52, 12517-12520.

20.Zhou, M.; Hu, J.; Zheng, M.; Song, Q.; Li, J.; Zhang, Y. Photo-click construction of a targetable and activatable two-photon probe imaging protease in apoptosis. Chem. Commun. 2016, 52, 2342-2345.

21.Tong, K.; Zheng, T. Y.; Zhang, Y.; Yu, S. Y. Synthesis of ortho-(Fluoro)alkylated Pyridines via Visible Light-Promoted Radical Isocyanide Insertion.Adv. Synth. Catal. 2015, 357, 3681-3686.

22.Wang, W.; Hu, J.; Zheng, M.; Zheng, L.; Wang, H.; Zhang, Y. Multi-responsive supramolecular hydrogels based on merocyanine-peptide conjugates. Org. Biomol. Chem. 2015, 13, 11492-11498.

23.Zheng, M.; Huang, H.; Zhou, M.; Wang, Y.; Zhang, Y.; Ye, D.; Chen, H. Y. Cysteine-Mediated Intracellular Building of Luciferin to Enhance Probe Retention and Fluorescence Turn-On. Chem. Eur. J. 2015, 21, 10506-10512.

24.Jiang, H.; An, X.; Tong, K.; Zheng, T.; Zhang, Y.; Yu, S. Visible-light-promoted iminyl-radical formation from acyl oximes: a unified approach to pyridines, quinolines, and phenanthridines. Angew. Chem. Int. Ed. 2015, 54, 4055-4059.

25.Tan, S. B.; Li, J.; Chen, X.; Zhang, W.; Zhang, D.; Zhang, C.; Li, D.; Zhang, Y. Small molecule inhibitor of myogenic microRNAs leads to a discovery of miR-221/222-myoD-myomiRs regulatory pathway. Chem. Biol. 2014, 21, 1265-1270.

26.Wang, R.; Jiang, H.; Cheng, Y.; Kadi, A. A.; Fun, H. K.; Zhang, Y.; Yu, S. Somophilic Isocyanide Insertion: Synthesis of 6-Arylated and 6-Trifluoro­methylated Phenanthridines.Synthesis, 2014, 46, 2711-2726.

27.Yang, K.; Zhang, C.; Wang, P.; Zhang, Y.; Ge, H. Nickel-catalyzed decarboxylative acylation of heteroarenes by sp2 C-H functionalization. Chem. Eur. J. 2014, 20, 7241-7244.

28.Jiang, H.; Cheng, Y.; Wang, R.; Zhang, Y.; Yu, S. Synthesis of isoquinolines via visible light-promoted insertion of vinyl isocyanides with diaryliodonium salts. Chem. Commun. 2014, 50, 6164-6167.

29.Li, J.; Kooger, R.; He, M.; Xiao, X.; Zheng, L.; Zhang, Y. A supramolecular hydrogel as a carrier to deliver microRNA into the encapsulated cells. Chem. Commun. 2014, 50, 3722-3724.

30.Li, J.; Tan, S.; Kooger, R.; Zhang, C.; Zhang, Y. MicroRNAs as novel biological targets for detection and regulation. Chem. Soc. Rev. 2014, 43, 506-517.

31.Jiang, H.; Cheng, Y.; Wang, R.; Zheng, M.; Zhang, Y.; Yu, S. Synthesis of 6-alkylated phenanthridine derivatives using photoredox neutral somophilic isocyanide insertion. Angew. Chem. Int. Ed. 2013, 52, 13289-13292.

32.  He, M.; Li, J.; Tan, S.; Wang, R.; Zhang, Y. Photodegradable supramolecular hydrogels with fluorescence turn-on reporter for photomodulation of cellular microenvironments. J. Am. Chem. Soc. 2013, 135, 18718-18721.