朱成建
职务： 院党委书记 博导
联系电话： 025-89683041
办公地址： 仙林化学楼
电子邮箱： cjzhu@nju.edu.cn
课题组主页： https://www.x-mol.com/groups/Zhu_chengjian
个人简介

威尼斯wnsr888(亚洲)集团有限公司教授，博士生导师，教育部新世纪人才。1996年于中科院上海有机所获博士学位，随后赴法国Universite de Bourgogne 以及美国 University of Oklahoma、University of Houston从事博士后研究。2000年加入威尼斯wnsr888(亚洲)集团有限公司，主要致力于金属有机化学研究，研究方向主要包括过渡金属催化的惰性C-H键官能化、可见光诱导的有机转化以及不对称催化合成。主持多项国家自然科学基金重点项目及科技部重大基础研究计划，以通讯作者在国际知名杂志 J. Am. Chem. Soc., Nature Commun., Angew. Chem. Int. Ed. ,  Acc. Chem. Res.,  Chem. Soc. Rev, ACS Catalysis等发表研究论文150余篇，H因子47，发表研究论文总共被引次数8100余次, 被引次数＞100次论文13篇。

主持研究项目：

  • 2002–2004   国家自然科学基金青年科学研究基金，“手性墙配体的合成及其金属配合物催化的不对称反应研究”

  • 2004-2007    国家自然科学基金重点项目，“导向有机合成的杂原子化学”

  • 2005-2007    国家自然科学基金面上项目，“软硬Lewis 酸协同导引的不对称合成反应研究”

  • 2007-2009    教育部新世纪优秀人才支持计划  

  • 2007-2009    国家自然科学基金面上项目，“不对称催化的多组分有机合成反应研究”

  • 2007-2011   科技部重大基础研究计划，“ 分子体系中的量子调控”

  • 2009-2012   国家自然科学基金重点项目，“前期过渡金属有机配合物的合成及应用”

  • 2010-2012  国家自然科学基金面上项目，“手性钼、铼配合物的合成及其导引的不对称反应”

  • 2012-2015   国家自然科学基金面上项目，“后过渡金属配合物的合成及其Sp3C-H键活化性能研究”

  • 2014-2017    国家自然科学基金面上项目，“光敏配合物的合成及其催化的C-H键官能化研究”

  • 2017-2020   国家自然科学基金面上项目，“过渡金属与可见光还原协同催化的惰性C-H键官能化研究"

  • 2018-2022   国家自然科学基金重点项目，“基于多元策略的可见光诱导电子转移反应新模式"

  • 2020-2023   国家自然科学基金面上项目，“基于可见光诱导惰性键均裂的含氟官能化反应研究"

专著及授权专利：

  • 林爱俊、朱成建, "串联的不对称催化反应", 《不对称催化新概念与新方法》, 丁奎岭、范青华主编, 化学工业出版社 2009年出版, 第9章, pp 250-287  

  • 朱成建、杨凤越, "稀土金属 Lewis 酸及手性稀土配合物催化的有机合成反应",《稀土金属有机化学》, 钱长涛、杜灿屏主编, 化学工业出版社 2004 年出版, 第10章, P311-351

  • 朱成建*，手性 2,5-二甲基-(或二异丙基)-1,4-环己二醇的制备方法. 中国，专利号: ZL 200310112774.5 (授权日期: 2006年8月23日)

  • 朱成建*，谢劲，胥攀，一种制备邻三氟甲基苯胺或衍生物的方法，中国， 专利号: ZL 2013 1 0528325.2 (授权日期: 2016年1月20日)

  • 朱成建*，金弘明，谢劲，一种制备3-甲基吲哚酮衍生物的方法，中国，专利号: ZL 2014 1 0049461.8 (授权日期: 2016年1月20日)




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工作经历

教育及工作经历

  • 1990–1993       中国科学院上海有机化学研究所攻读硕士学位

  • 1993–1996       中国科学院上海有机化学研究所攻读博士学位

  • 1997–1998       法国 Universite de Bourgogne 从事博士后研究

  • 1998–1999       美国 University of Oklahoma 从事博士后研究

  • 1999–2000       美国 University of Houston 从事博士后研究

  • 2000–2003       威尼斯wnsr888(亚洲)集团有限公司副教授

  • 2003–至今       威尼斯wnsr888(亚洲)集团有限公司教授

获奖情况

1. 教育部新世纪人才（2005年）

2. Eli Lilly优秀研究生论文指导导师（2012年）

3. 江苏省优秀博生论文指导导师（2014年）

4. 宝钢优秀教师奖（2014年）

学术交流活动：

  • 2019.11    第二届国际有机光化学合成学术论坛，大会报告， 南昌大学

  • 2019.10  1st international green and substainable chemistry conference， 邀请报告，北京

  • 2019. 9   ChemShip-2019 Organometallic Chemistry Around the World (7th Razuvaev Lectures) ChemShip-2019年世界金属有机第7届Razuvaev报告会，大会报告， Nizhny Novgorod, Russia（下诺夫哥罗德，俄罗斯）

  • 2019. 7   20th IUPAC International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis IUPAC第20届国际金属有机合成化学会议，大会报告，Heidelberg, Germany （德国海德堡）




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研究方向


课题小组主要致力于发展后过渡金属催化以及光氧化还原催化的方法学来高效构建氮杂环化合物以及含氟化合物，探讨其潜在的生物活性。同时也致力于开发寻找新的有机功能材料。

研究方向主要包括：一、过渡金属诱导的惰性C-H键官能化研究；二、可见光诱导的有机转化；三、不对称催化合成

学术成果




2020


149. Congjun Zhu, Jie Dong, Xueting Liu, Liuzhou Gao, Yue Zhao, Jin Xie*, Shuhua Li*, Chengjian Zhu*,  Angew. Chem. Int. Ed.2020, DOI: 10.1002/anie.202005749.https://onlinelibrary.wiley.com/doi/full/10.1002/anie.202005749



2019

148.  Yiyun Chen*, Liang-Qiu Lu*, Da-Gang Yu*, Cheng-Jian Zhu* , Wen-Jing  Xiao*, Visible light-drivenorganic photochemical synthesis in China , Sci China Chem, 2019, 62: 24–57

147. Rehanguli Ruzi, Junyang Ma, Xiang-Ai Yuan, Wenliang Wang, Shanshan Wang, Muliang Zhang, Jie Dai, Jin Xie* and Chengjian Zhu*, Deoxygenative Arylation of Carboxylic Acids via Aryl Migration,Chem. Eur. J. 2019, 25, 12724- 12729



146. Wentao Xu, Wenliang Wang, Tao Liu, Jin Xie*, Chengjian Zhu*, Late-Stage Trifluoromethylthiolation of Benzylic C-H Bonds, Nature Commun.2019, 10, 4867

145.  Weipeng Li, Dandan Yuan, Guoqiang Wang, Yue Zhao, Jin Xie,*Shuhua Li,*and Chengjian Zhu*,Cooperative Au/Ag Dual-Catalyzed Cross-Dehydrogenative Biaryl Coupling: Reaction Development and Mechanistic Insight,J. Am. Chem. Soc. 2019,141, 3187.

2018

144.  Zhongfei Yan, Chengjian Zhu, Jin Xie*,Manganese(I)-Catalyzed Selective Functionalization of Alkynes, Synlett , 2018, 29, 124.

143.Zhongfei Yan, Xiang-Ai Yuan, Yue Zhao, Chengjian Zhu and Jin Xie*, A Dimeric Mn-Catalyzed Completely Selective Hydroarylation of 1,3-Diynes for the Modular Synthesis of (Z)-Enynes Library,Angew. Chem. Int. Ed. 2018,57, 12906.

142.  Muliang Zhang, Jin Xie*, Chengjian Zhu*, A General Deoxygenation Approach for Synthesis of Ketones from Aromatic Carboxylic Acids and Alkenes, Nature Commun. 2018, 9, 3517.

141.Wentao Xu, Junyang Ma, Xiang-Ai Yuan, Jie Dai, JinXie*, Chengjian Zhu*,Synergistic Catalysis for the Umpolung Trifluoromethylthiolation of Tertiary Ethers, Angew. Chem. Int. Ed.2018, 57, 10357.

140.Nengneng Zhou, Xiang-Ai Yuan, Yue Zhao, Jin Xie* and Chengjian Zhu*, Synergistic Photoredox Catalysis and Organocatalysis for Inverse Hydroboration of Imines, Angew. Chem. Int. Ed. 2018,57, 3990.

139. Pan Xu,Weipeng Li,JinXie*,Chengjian Zhu*,''Exploration of C-H Transformation of Aldehyde Hydrazones: Radical Strategy and Beyond'', Acc. Chem. Res., 2018,51, 484.

138. Weipeng Li, Wentao Xu, Jin Xie, * Shouyun Yu *, Chengjian Zhu *, ''Distal radical migration strategy: an emerging synthetic means'',Chem. Soc. Rev., 2018, 47, 654. 高引用论文


137.Jian Cheng, Jin Xie,* Chengjian Zhu*, ''Relay Photocatalytic Cascade Reaction: Synthesis of Indolo[2,1-a]isoquinoline Derivatives via Double C(sp3)-H Bonds Functionalization'',Chem. Commun., 2018, 54, 1655.

136.Muliang Zhang, Rehanguli Ruzi, Nan Li, Jin Xie*, Chengjian Zhu*, ''Photoredox and Cobalt Co-catalyzed C(sp2)-H Functionalization/C-O Bond Formation for Synthesis of Lactones Under Oxidant- and Acceptor-Free Conditions'',Org. Chem. Front., 2018,5, 749.



135.Jing Liu, Weipeng li, Jin Xie*, Chengjian Zhu*, Photoredox 1,2-Dicarbofunctionalization of Unactivated Alkenes via Tandem Radical Difluoroalkylation and Alknyl Migration, Org. Chem. Front., 2018,5, 797. 高引用论文

2017

134. Jian Cheng, Yixiang Cheng, Jin Xie,* Chengjian Zhu*, ''Photoredox Divergent 1,2-Difunctionalization of Alkenes with Gem-dibromides'',Org. Lett.,2017, 19, 6452.

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133.Rehanguli Ruzi, Muliang Zhang , Keyume Ablajan*, Chengjian Zhu*, Photoredox-Catalyzed Deoxygenative Intramolecular Acylation of Biarylcarboxylic Acids: Access to Fluore-nones, J. Org. Chem.2017, 82, 12834.

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132.Zhongfei Yan, Jin Xie*, Chengjian Zhu*, Copper-Catalyzed Radical Silylarylation of Ynones with Silanes: En Route to Silyl-Functionalized Indenones, Adv. Synth. Catal., 2017,359, 4153.

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131. Nengneng Zhou,Yixiang Cheng, Jin Xie*, Chengjian Zhu*,Harnessing sunlight without a photosensitizer for highly efficient consecutive [3+2]/[4+2] annulation to synthesize fused benzobicyclic skeletons, Chem. Commun., 2017, 53, 10707.

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130. Jing Liu, Jin Xie,* Chengjian Zhu*,Photoredox organocatalytic α-amino C(sp3)-H Functionalization for the synthesis of 5-membered heterocyclic γ-amino acid derivatives, Org. Chem. Front., 2017,4, 2433.

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129. Muliang Zhang,Nan Li, Xingyu Tao, Rehanguli Ruzi, Shouyun Yu*,  Chengjian Zhu*, Selective Reduction of Carboxylic Acids to Aldehydes with Hydrosilane via Photoredox Catalysis, Chem. Commun., 2017, 53, 10228.

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128. Muliang Zhang, Junwei Xi, Rehanguli  Ruzi, Nan Li, Zhongkai Wu,  Weipeng Li, Chengjian Zhu*, Domino-fluorination-protodefluorination enables decarboxyla-tive cross-coupling of α-oxocarboxylic acids with styrene via photoredox catalysis, J. Org. Chem.,2017,82, 9305.

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127.Muliang Zhang, Rehanguli ▪ Ruzi, Junwei Xi, Nan Li, Zhongkai Wu, Weipeng Li, ShouyunYu*, Chengjian Zhu*, Photoredox-Catalyzed Hydroacylation of OlefinsEmploying Carboxylic Acids and Hydrosilanes, Org. Lett.,2017, 19, 3430. ( Top 3 most read in June )

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126. Honglin Zhang, Chengjian Zhu*,Iron-Catalyzed Cascade Cyanoalkylation/Radical Dearomatization of N-phenylcinnamamides: Access to Cyanoalkylated 1-Azaspiro[4.5]decanes, Org. Chem. Front., 2017,4, 1272 .

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125.Chuanhua Qu, Zhongkai Wu, Weipeng Li, Hongbin Du*, Chengjian Zhu*, Electron Catalytic Photochemical Cascade Carbodifluoroalkylation /Radical Cyclization of Methylene-2-oxazolines, Adv. Synth. Catal., 2017,359, 1672.(VIP)

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124.Nengneng Zhou,  Jing Liu,  Zhongfei Yan,  Zhongkai Wu,  Honglin Zhang, Weipeng Li , Chengjian Zhu*, Synthesis of cyclohexylidenehydrazines-fused polycyclics via photocatalytic radical cascade reaction of 2-ethynylaldehyde hydrazones, Chem. Commun., 2017, 53, 2036.

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123. Honglin Zhang, Weipeng Li, Chengjian Zhu*, Copper-catalyzed cascade phosphorylation initiated radical cy-clization: access to 2-phosphorylated-pyrrolo[1,2-a]indole, J. Org. Chem.2017, 82, 2199.

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122. Yingqian Duan+, Muliang Zhang+, Rehanguli Ruzi, Zhongkai Wu, Chengjian Zhu*, The Direct Decarboxylative Allylation of N-arylglycine Derivates by Photoredox Catalysis, Org. Chem. Front., 2017,525. ( Y. Duan and M. Zhang contributed equally to this work).

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121.  Zhongkai Wu, Pan Xu, Nengneng Zhou, Yingqian Duan, Muliang Zhang, Chengjian Zhu*,[3+2] Cycloaddition of azide with aldehyde hydrazone through an aminyl radical-polar crossover strategy, Chem. Commun., 2017, 53,1045.

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120. Jian Cheng, Weipeng Li, Yingqian Duan, Yixiang Cheng, Shouyun Yu* , Chengjian Zhu*, Relay Visible Light Photoredox Catalysis: Synthesis of Pyrazole Derivatives via Formal [4+1] Annulation and Aromatization, Org. Lett.2017, 19, 214.

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119.  Pan Xu, Guoqiang Wang, Zhongkai Wu, Shuhua li* and Chengjian Zhu*, Rh(III)-catalyzed double C-H activation of aldehyde hydrazones: en route to functionalized 1H-Indazole synthesis,Chem. Sci. 2017,8, 1303.

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118. Zhou Nengneng, Xu Pan, Li Weipeng, Cheng Yixiang, Zhu Chengjian*, Visible light promoted carbodifluoroalkylation of homopropargylic alcohols via concomitant 1,4-aryl migration,  Acta Chim. Sinica. 2017, 75, 60.

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2016

117.Nengneng Zhou, Zhongfei Yan, Honglin Zhang, Zhongkai Wu and Chengjian Zhu*,  Metal-free radical Oxidative Cyclization of o-Azidoaryl Acetylenic Ketones with Sulfinic acids to Access Sulfone-Containing 4-Quinolones, J. Org. Chem. 2016, 81, 12181.

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116.Chuanhua Qu, Songlin Zhang, Hongbin Du* and Chengjian Zhu*, Cascade photoredox/gold catalysis: access to multisubstituted indoles via aminoarylation of alkynes, Chem. Comm. 2016, 52, 14400.

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115.Yingqian Duan, Weipeng Li, Pan Xu, Muliang Zhang, Yixiang Cheng and Chengjian Zhu*, Visible-light-induced three-component 1,2-difluoroalkylarylation of styrenes with α-carbonyl difluoroalkyl bromides and indoles, Org. Chem. Front., 2016, 3,1443.

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114.Muliang Zhang, Yingqian Duan, Weipeng Li, Pan Xu, Jian Cheng, Shouyun Yu*, and Chengjian Zhu*, A Single Electron Transfer (SET) Approach to C–H Amidation of Hydrazones via Visible-Light Photoredox Catalysis, Org. Lett. 2016, 18, 5356.

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113. Jian Cheng, Pan Xu, Weipeng Li, Yixiang Cheng and Chengjian Zhu*, The Functionalization of a Cascade of C(sp2)-H/C(sp3)-H Bonds: Synthesis of Fused Dihydropyrazoles via Visible-light Photoredox Catalysis, Chem. Comm. 2016, 52, 11901.

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112. Muliang Zhang, Weipeng Li,Yingqian Duan, Pan Xu, Songlin Zhang, Chengjian Zhu*,'' Cascade Photoredox/Iodide Catalysis: Access to Difluoro-γ-lactams via Aminodifluoroalkylation of Alkenes, Org. Lett. 2016, 18, 3266.


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111. Weipeng Li, Yingqian Duan, Muliang Zhang, Jian Cheng, and Chengjian Zhu*, '' Photoredox Catalyzed Radical-Radical Coupling Reaction: Facile Access to Multi-Substitued Nitrogen Heterocycles, Chem. Comm. 2016, 52, 7596.


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110. Guoqiang Wang, Honglin Zhang, Jiyang Zhao,Wei Li, Jia Cao, Chengjian Zhu*, and Shuhua Li,*  Homolytic Cleavage of a B−B Bond by the Cooperative Catalysis of Two Lewis Bases: Computational Design and Experimental Verification , Angew.Chem. Int. Ed. 2016, 55, 5985.


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109. Muliang Zhang, Yingqian Duan, Weipeng Li, Yixiang Cheng and Chengjian Zhu*, ''Visible-Light-Induced Aerobic Dearomative Reaction of Indole Derivatives: Access to Heterocycle Fused or Spirocyclo Indolones'', Chem. Comm., 2016, 52, 4761.

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108. Pan Xu, Zhongkai Wu, Nengneng Zhou, Chengjian Zhu*, ''Oxidative C(sp2)–H Phosphonation of Aldehyde Hydrazones''. Org. Lett. 2016, 18, 1143.

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107. Jin Xie and Chengjian Zhu, Sustainable C(sp3)-H Bond Functionalization, Springer, 2016 (Invited Book, ISBN:978-3-662-49494-3).

106. Honglin Zhang, Zhangxi Gu, Zhenyi Li, Changduo Pan, Weipeng Li, Hongwen Hu, and Chengjian Zhu*, '' Silver-Catalyzed  Cascade Radical Cyclization: A Direct Approach to 3,4-Disubstituted Dihydroquinolin-2(1H)-ones through Activation of the P–H Bond and Functionalization of the C(sp2)–H Bond '', J. Org. Chem.2016, 81, 2122

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105. Pan Xu, Guoqiang Wang, Yuchen Zhu, Weipeng Li, Yixiang Cheng, Shuhua Li* and Chengjian Zhu*, '' Visible-Light Photoredox-Catalyzed C-H Difluoroalkylation of Hydrazones through an Aminyl Radical/Polar Mechanism'', Angew.Chem. Int. Ed. 2016, 55, 2939. web of science 热点论文

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104. Honglin Zhang, Zhangxi Gu, Pan Xu, Hongwen Hu, Yixiang Cheng and Chengjian Zhu*, '' Metal-free tandem oxidative C(sp3)–H bond functionalization of alkanes and dearomatization of N-phenyl-cinnamamides: access to alkylated 1-azaspiro[4.5]decanes'', Chem. Comm., 2016, 52, 477.

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