1990年毕业于武汉大学化学系

1997、2000年在南京大学分别获得硕士和博士学位

2007年入选教育部“新世纪优秀人才支持计划”

2011-2014年获得国家杰出青年科学基金资助

2013年获得中国青年女科学家奖

2014年入选英国皇家化学会会士

2014入选教育部长江学者特聘教授

现为Scientific Reports、VIEW、《化学学报》、《分析化学》、《分析科学学报》等刊编委

2019年9月起任中国化学会质谱专业委员会副秘书长

2019年1月起任Analytica Chimica Acta的Editor

2000.8-2003.6 威尼斯wnsr888(亚洲)集团有限公司 博士、讲师

2003.7-2006.6 威尼斯wnsr888(亚洲)集团有限公司 副教授

2006.7-至今  威尼斯wnsr888(亚洲)集团有限公司 教授

2007/2008年度  美国康奈尔大学访问教授

研究方向:生命分析化学（光、电分析化学、生物传感、单细胞分析、微纳尺度生物分析）

课题组近五年代表性成果：

1.       Yi-Fan Ruan, Feng-Zao Chen, Yi-Tong Xu, Tian-Yang Zhang, Si-Yuan Yu, Wei-Wei Zhao,* Dechen Jiang, Hong-Yuan Chen and Jing-Juan Xu*，An Integrated Photoelectrochemical Nanotool for Intracellular Drug Delivery and Treatment Effect Evaluation，Angew. Chem. Int. Ed. 2021, 60, 25762–25765, DOI: 10.1002/anie.202111608 and 10.1002/ange.202111608

2.       Ming-Ming Chen, Cong-Hui Xu, Wei Zhao*, Hong-Yuan Chen, Jing-Juan Xu, Super-Resolution Electrogenerated Chemiluminescence Microscopy for Single Nanocatalysts Imaging, J. Am. Chem. Soc. 2021, 143, 44, 18511–18518 DOI: 10.1021/jacs.1c07827

3.       Pei Song, He Gao, Zhao-Shuai Gao, Jia-Xing Liu, Rui-Ping Zhang, Bin Kang*, Jing-Juan Xu* and Hong-Yuan Chen*, Heat transfer and thermoregulation within single cells revealed by transient plasmonic imaging, Chem,2021，7（6），1569-1587 DOI: 10.1016/j.chempr.2021.02.027

4.       Jun Hu, Ting Wang, Wen-Jun Zhang, Han Hao, Qiao Yu, Hang Gao, Nan Zhang, Yun Chen,* Xing-Hua Xia, Hong-Yuan Chen, Jing-Juan Xu*, Dissecting the Flash Chemistry of Electrogenerated Reactive Intermediates by Microdroplet Fusion Mass Spectrometry, Angew. Chem. Int. Ed.,2021, 60, 18494–18498 DOI: 10.1002/anie.202106945

5.       Hai-Yan Wang, Yi-Fan Ruan, Li-Bang Zhu, Xiao-Mei Shi, Wei-Wei Zhao,* Hong-Yuan Chen and Jing-Juan Xu*, An Integrated Electrochemical Nanodevice for Intracellular RNA Collection and Detection in Single Living Cell, Angew. Chem. Int. Ed., 2021, 60,13244–13250 DOI: 10.1002/anie.202014798

6.       Yizhong Shen, Yiyin Zhang, Zhong Feng Gao, Yingwang Ye*, Qingping Wu, Hong-Yuan Chen, Jing-Juan Xu^*, Recent advances in nanotechnology for simultaneous detection of multiple pathogenic bacteria, Nano Today, 2021, 38, 101121  DOI: 10.1016/j.nantod.2021.101121

7.       Ming-Ming Chen, Hai-Li Hao, Wei Zhao*, Xueli Zhao, Hong-Yuan Chen, Jing-Juan Xu*, A Plasmon-Enhanced Theranostic Nanoplatform for Synergistic Chemo-Phototherapy of Hypoxic Tumors in the NIR-II Window, Chem. Sci., 2021, 12, 10848 – 10854 DOI: 10.1039/D1SC01760H

8.       Wei Zhao, Hong-Yuan Chen, Jing-Juan Xu*, Electrogenerated Chemiluminescence Detection of Single Entities, Chem. Sci., 2021, 12, 5720 – 5736 DOI: 10.1039/D0SC07085H

9.       He Gao, Pei Wu , Pei Song, Bin Kang*, Jing-Juan Xu* and Hong-Yuan Chen，The Video-rate imaging of sub-10 nm plasmonic nanoparticles in a cellular medium free of background scattering, Chem. Sci., 2021, 12, 3017 – 3024 DOI: 10.1039/D0SC04764C

10.    Jun Hu, Nan Zhang, Pan-Ke Zhang, Yun Chen, Xing-Hua Xia, Hong-Yuan Chen, Jing-Juan Xu*, Coupling a Wireless Bipolar Ultramicroelectrode with Nano-electrospray Ionization Mass Spectrometry: Insights into the Ultrafast Initial Step of Electrochemical Reactions, Angew. Chem. Int. Ed., 2020, 59, 18244-18248 DOI: 10.1002/anie.202008577

11.    Zhaoshuai Gao, Jian-Hua Wang, Pei Song, Bin Kang,* Jing-Juan Xu, and Hong-Yuan Chen, Spaser Nanoparticles for Ultranarrow Bandwidth STED Super-Resolution Imaging, Adv. Mater., 2020, 32, 1907233 DOI: 10.1002/adma.201907233

12.    Ziyu Wang, Jianbin Pan, Qian Li, Yi Zhou, Sen Yang, Jing-Juan Xu* and Daoben Hua*，Improved AIE-Active Probe with High Sensitivity for Accurate Uranyl Ion Monitoring in the Wild Using Portable Electrochemiluminescence System for Environmental Applications, Adv. Funct. Mater., 2020, 30, 2000220 DOI: 10.1002/adfm.202000220

13.    Xing Wei, Meng-Jiao Zhu, Zhe Cheng, Mengjue Lee, Hong Yan*, Changsheng Lu* and Jing-Juan Xu*, Aggregation-Induced Electrochemiluminescence of Carboranyl Carbazoles in Aqueous Media, Angew. Chem. Int. Ed. 2019, 58, 3162 –3166, DOI: 10.1002/anie.201900283

14.    Hui Wang, Wei Zhao, Cong-Hui Xu*, Hong-Yuan Chen, Jing-Juan Xu*, Electrochemical Synthesis of Au@Semiconductor Core-Shell Nanocrystals Guided by Single Particle Plasmonic Imaging,Chem Sci  2019, 10, 9308 – 9314 DOI: 10.1039/C9SC02804H

15.    Ming-Ming Chen, Wei Zhao, Meng-Jiao Zhu, Xiang-Ling Li, Cong-Hui Xu,* Hong-Yuan Chen, Jing-Juan Xu*, Spatiotemporal Imaging of Electrocatalytic Activity on Single 2D Gold Nanoplates via Electrogenerated Chemiluminescence Microscopy†, Chem Sci2019, 10, 4141 - 4147 DOI: 10.1039/C9SC00889F

16.    Hong Zhou, Jing Liu, Jing-Juan Xu,* Shusheng Zhang* and Hong-Yuan Chen, Optical Nano-Biosensing Interface via Nucleic Acid Amplification Strategy: Construction and Application, Chem Soc Rev, 2018, 47, 1996 - 2019

17.    Pei Song, Jian-Hua Wang, Miao Zhang, Fan Yang, Hai-Jie Lu, Bin Kang*, Jing-Juan Xu*, Hong-Yuan Chen*, Three-level spaser for next generation luminescent nanoprobe, Sci Adv 4, eaat0292 (2018).doi: 10.1126/sciadv.aat0292

18.    Juan Song, Cong-Hui Xu, Shi-Zhen Huang, Wen Lei, Yi-Fan Ruan, Hai-Jie Lu, Wei Zhao*, Jing-Juan Xu*, Hong-Yuan Chen, Ultrasmall Nanopipette: Toward Continuous Monitoring of Redox Metabolism at Subcellular Level, Angew. Chem. Int. Ed. 2018, 57, 13226 –13230 DOI: 10.1002/anie.201808537

19.    Meng-Jiao Zhu, Jian-Bin Pan, Zeng-Qiang Wu, Xiao-Yu Gao, Wei Zhao*, Xing-Hua Xia, Jing-Juan Xu* and Hong-Yuan Chen, Electrogenerated Chemiluminescence Imaging of Electrocatalysis at a Single Au-Pt Janus Nanoparticle, Angew. Chem. Int. Ed. 2018, 57, 4010 –4014（10.1002/anie.201800706）

20.    Mei-Xing Li, Cong-Hui Xu, Nan Zhang, Guang-Sheng Qian, Wei Zhao,* Jing-Juan Xu* and Hong-Yuan Chen, Exploration of the Kinetics of Toehold Mediated Strand Displacement via Plasmon Rulers, ACS Nano 2018, 12, 3341-3350 DOI: 10.1021/acsnano.7b08673

21.    Ting-Ting Zhang, Cong-Hui Xu, Wei Zhao, Yu Gu, Xiang-Ling Li*, Jing-Juan Xu*, Hong-Yuan Chen, A Redox-Activated Theranostic Nanoagent: Toward Multi-Mode Imaging Guided Chemo-Photothermal Therapy, Chem Sci 2018, 9, 6749 – 6757, DOI: 10.1039/C8SC02446D

22.    Fan Yang, He Gao, Shan-Shan Li, Rui-Bing An, Xiao-Yang Sun, Bin Kang*, Jing-Juan Xu*, Hong-Yuan Chen, A fluorescent t-probe: quantitative imaging of ultra-trace endogenous hydrogen polysulfide in cells and in vivo, Chem Sci 2018, 9, 5556 – 5563   

23.    Yu Gu, Ting-Ting Zhang, Zhi-Feng Huang, Shan-Wen Hu, Wei Zhao*, Jing-Juan Xu* and Hong-Yuan Chen, An Exploration of Nucleic Acid Liquid Biopsy Using a Glucose Meter, Chem Sci 2018, 9, 3517 – 3522

24.    Yizhong Shen,Yidan Sun, Runqi Yan, Erquan Chen, Huan Wang, Deju Ye*, Jing-Juan Xu*, Hong-Yuan Chen*, Rational engineering of semiconductor QDs enabling remarkable ¹O₂ production for tumor-targeted photodynamic therapy, Biomaterials, 2017, 148, 31-40

25.    Shan-Shan Li, Qi-Yuan Guan, Mengmeng Zheng, Yu-Qi Wang, Deju Ye, Bin Kang,* Jing-Juan Xu,* and Hong-Yuan Chen*, Simultaneous quantification of multiple endogenous biothiols in single living cells by plasmonic Raman probes, Chem Sci, 2017, 8, 7582 - 7587

26.    Kai Zhang, Xue-Jiao Yang, Wei Zhao,* Ming-Chen Xu, Jing-Juan Xu*, and Hong-Yuan Chen, Regulation and Imaging of Gene Expression via an RNA Interference Antagonistic Biomimetic Probe, Chem Sci, 2017, 8, 4973 – 4977

27.    Bing Kang, Shan-Shan Li, Qi-Yuan Guan, Ai-Ping Chen, Pan-Ke Zhang, Li-Bin Zhang, Ji-Wu Wei, Jing-Juan Xu,*, Hong-Yuan Chen,*Plasmon-enhanced Raman spectroscopic metrics for in situ quantitative and dynamic assays of cell apoptosis and necrosis, Chem Sci,2017, 8, 1243 - 1250  

28.    Linfeng Sheng, Lesi Cai, Jie Liu, Sichun Zhang, Jing-Juan Xu,* Xinrong Zhang,* Hong-Yuan Chen, Imaging specific newly synthesized proteins within cells by fluorescence resonance energy transfer, Chem Sci, 2017, 8, 748 – 754

研究生课程：电化学研究方法

授课对象：化院研一新生

授课时间：秋季学期

授课形式和成绩考核

授课形式：多媒体+专题讨论

成绩考核：平时成绩 + 专题演讲 + 期末论文

推荐使用的主要参考书

1．A.J.Bard and L.R.Faulkner, Electrochemical methods, fundamentals and applications (2nd Edition), John Wiley & Sons, 2001

2. 阿伦.J.巴德，拉里.R.福克纳著，邵元华，朱果逸等译，电化学方法－原理和应用（第二版），化学工业出版社，2005

3. 吴浩青，李永舫，电化学动力学，高等教育出版社，1998

4. 查全性，电极过程动力学导论（第三版），科学出版社，2002

招聘信息：课题组常年招聘专职科研人员、博士后

专职科研人员：

宋  娟 副研究员

周宇扬 博士后（在职-苏州科技大学）

王忠霞 博士后（在职-盐城工学院）

王成双 博士后（在职-盐城工学院）

吕松伟 博士后（在职-常州大学）

史笑梅 博士后

高  杭 博士后

博士生：

雷雯、王海燕、周洁、王惠、陈明明、王璐璇、余巧、李庆悦、李晓琼、吕品田、徐一童、王冰、王靖薷、王泽鸿、席晓君

硕士生：

罗丹、浩海丽、张仙、张钰雯、赵子媛、郑有为、周冰煜