| 题 目：Self-Disproportionation of Enantiomers: A Manifesto 报告人：Prof. Vadim A. Soloshonok 单 位：Department of Chemistry and Biochemistry, The University of Oklahoma Past Chair, Division of Fluorine Chemistry, The American Chemical Society 时 间：2010年4月6日（星期二）上午10：00 地 点：化学楼三楼报告厅 Biosketch: Vadim A. Soloshonok was born in 1961 in Dnepropetrovsk City, Ukraine, Soviet Union. He graduated from Kiev State University (1983) and received his Ph.D. (1987) from Ukrainian Academy of Sciences (Thesis Director: Academician, Prof. V. Kukhar). He became a Research Associate of The Institute of Bioorganic Chemistry and promoted to a Senior Research Associate (1987-1995) there. He continued his training in the area of asymmetric synthesis, in general, and α- and β-amino acids, in particular, in collaboration with Professors P. Bravo (Milan, Italy, 1993), Y. N.. Belokon’ (Moscow, USSR, 1987-1990), T. Hayashi (Sapporo, Japan, 1994-1995) and V. Hruby (Tucson, USA, 1998-2000). Since 2001 he is a Professor of Chemistry at the University of Oklahoma. Abstract: Separation of racemate from the excess enantiomer is known for as long as chemists first attempted to crystallize non-racemic compounds, resulting in the formation of correspondingly enantiomerically enriched and depleted fractions. On the other hand, observations of the same phenomenon under routine and totally achiral conditions of fractional distillation, evaporation, AP-chromatography, sublimation and density gradient centrifugation are substantially not-so-common and, generally, still remain to be unknown to the most practitioners in chemistry. Not surprisingly, the recent publications in this area have attracted considerable interest of scientific community and were highlighted in Science, Angew. Chem. With more results being published, it becomes more and more obvious that general implications of this phenomenon are far-reaching, ranging from problems with reliable routine determination of the stereochemical outcome of asymmetric reactions to the development of conceptually new technology for optical purification procedures. Of particular interest is an implication of this phenomenon in the formation of pre-biotic homo-chirality as a pre-requisite for the emergence of life. This talk will present the author’s new concept of “chiral annihilation” as totally natural and general phenomenon leading to homochirality in certain areas of second-generation galaxies which can support the Earth-like life form. 欢迎大家参加！ 有机化学学科 配位化学国家重点实验室 |